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Topical Ciprofloxacin vs Topical Gentamicin

Alper Tutkun, MD; Altug Özagar, MD; Ahmet Koç, MD; Caglar Batman, MD; Cüneyd Üneri, MD; Mehmet Ali Sehitoglu, MD

Arch Otolaryngol Head Neck Surg. 1995;121(12):1414-1416.

Abstract
Objective
To determine and compare the therapeutic efficiency of ciprofloxacin hydrochloride and gentamicin sulfate in the treatment of chronic ear disease.

Design
Prospective randomized study.

Setting
Academic tertiary medical center.

Patients
Consecutive referred sample of 44 patients with chronic suppurative otitis media randomized into two groups.

Interventions
Ciprofloxacin hydrochloride (200 mg/mL) was administered to the first group (composed of 24 patients), while the second group (composed of 20 patients) received gentamicin sulfate (5 mg/mL) locally, five drops three times a day for 10 days.

Results
In the ciprofloxacin group, 21 (88%) of the 24 patients with suppurative chronic otitis media were cured. On the other hand, only six (30%) of the patients in the gentamicin group were cured. The rest of the patients showed no clinical or bacteriological improvement.

Conclusions
To our knowledge, this is the first study to compare the efficiency of two topical otic preparations in the treatment of chronic ear disease. The results show that topical ciprofloxacin preparation is more efficacious and efficient than topical gentamicin for the treatment of chronic otitis media in the acute stage.

(Arch Otolaryngol Head Neck Surg. 1995;121:1414-1416)

Author Affiliations
From the Ear, Nose, and Throat Department, Faculty of Medicine, Marmara University, Istanbul, Turkey.

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