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Håkan Einer, MD; Lilian Tengborn, MD, PhD; Alf Axelsson, MD, PhD; Staffan Edström, MD, PhD

Arch Otolaryngol Head Neck Surg. 1994;120(5):536-540.

Abstract
Objective
To evaluate the possible causal role of pathologic hemostatic mechanisms in sudden hearing loss.

Design
The study was prospective.

Setting
The patients were hospitalized, and all tests were performed at the hospital.

Patients
Thirty-two consecutive patients with sudden hearing loss participated, as well as a control group of 28 healthy individuals. The control group was matched with regard to body mass index.

Main Outcome Measures
Venous blood analyses were made regarding general blood parameters, as well as specific hemostatic parameters.

Results
Twenty-five of the patients had some kind of aberration of specific hemostasis parameters; seven patients had an increase in the activity of the plasminogen activator inhibitor 1 (ie, a glycoprotein associated with diminished fibrinolysis) compared with that in the control group (P<.05). Increased plasminogen activator inhibitor levels were most frequently observed among the patients who were overweight. Seven of the oldest patients had an increase of D-dimers, ie, a degradation product of fibrin, and most of these patients had a history of cardiovascular disease.

Conclusion
Although isolated aberrations in the hemostatic pathway were observed, we concluded that pathologic hemostasis does not seem to have a decisive importance for the pathogenesis of sudden deafness.

(Arch Otolaryngol Head Neck Surg. 1994;120:536-540)

Author Affiliations
From the Departments of Otolaryngology—Head and Neck Surgery (Drs Einer, Axelsson, and Edström) and Internal Medicine (Dr Tengborn), Sahlgrenska Hospital, University of Göteborg (Sweden).

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ABSTRACT