This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Susan A. Eicher, MD; Linda D. Taylor-Cooley, MD; Donald T. Donovan, MD

Arch Otolaryngol Head Neck Surg. 1994;120(4):405-409.

Abstract
Retinoic acid has been advocated for use in several premalignant and malignant epithelial lesions of the head and neck, including benign recurrent respiratory papillomatosis, with varying results. We describe a 24-year-old man with extensive tracheoesophageal and bronchoalveolar papillomatosis that degenerated into squamous cell carcinoma. Multiple endoscopic carbon dioxide laser excisions, at one point performed on a weekly basis, as well as a prolonged trial of interferon, failed to control the progression of his disease. Isotretinoin (13-cis-retinoic acid) therapy (1 mg/kg per day) was instituted, with dramatic clinical, radiographic, and functional improvement. The patient experienced no significant toxic effects and required no endoscopic procedures over a 6-month period. We propose that isotretinoin may be an effective adjuvant therapy for aggressive respiratory papillomatosis.

(Arch Otolaryngol Head Neck Surg. 1994;120:405-409)

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Recurrent Respiratory Papillomatosis in Children: Masquerader of Common Respiratory Diseases
Zacharisen and Conley
Pediatrics 2006;118:1925-1931.
ABSTRACT | FULL TEXT  

Isotretinoin in Respiratory Papillomatosis
Osborne et al.
ANN INTERN MED 2000;132:1007-1007.
FULL TEXT