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Emotional Status and Botulinum Toxin Treatment

Thomas Murry, PhD; Michael P. Cannito, PhD; Gayle E. Woodson, MD

Arch Otolaryngol Head Neck Surg. 1994;120(3):310-316.

Abstract
The objectives of this study were to determine the effects of botulinum toxin injection on measures of depression, anxiety, and somatic complaints in patients diagnosed as having spasmodic dysphonia. Patients were asked to complete preinjection questionnaires with self-ratings of depression, state and trait anxiety, and somatic complaints. Approximately 1 week and 2 months following injection, patients were again asked to complete the questionnaires. The spasmodic dysphonic subjects exhibited significantly elevated mean levels of depression and anxiety. These levels were significantly reduced approximately 1 week after injection. Two months later, depression and anxiety measures did not change significantly from their 1-week postinjection values. The results suggest that patients with spasmodic dysphonia who demonstrate significantly elevated measures of depression and anxiety show a reduction in those measures following treatment with botulinum toxin.

(Arch Otolaryngol Head Neck Surg. 1994;120:310-316)

Author Affiliations
From the Department of Otolaryngology—Head and Neck Surgery, University of Tennessee College of Medicine, Memphis (Drs Murry and Woodson), and the Speech and Hearing Center, University of South Alabama, Mobile (Dr Cannito). Drs Murry and Woodson are now with the Department of Otolaryngology–Head and Neck Surgery, University of Tennessee, Memphis.

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