Immunohistochemical Detection of c-myc Protein in Head and Neck Tumors
Markus Gapany, MD;
Zlatko P. Pavelic, MD, PhD;
Daniel J. Kelley, MD;
Ljiljana Pavelic;
Sabina R. Gapany;
James M. Craven, MD;
Peter J. Stambrook, PhD;
Jack L. Gluckman, MD
Arch Otolaryngol Head Neck Surg. 1994;120(3):255-259.
Abstract
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Objectives
To evaluate the correlation between the levels of immunohistochemically detectable c-myc protein in squamous cell carcinoma of the head and neck and clinicopathologic prognostic variables utilized in clinical practice.
Design
Cohort study.
Setting
University and Veterans Administration medical centers, Cincinnati, Ohio.
Patients or Other Participants
Consecutive samples.
Intervention
Surgery for squamous cell carcinoma of the head and neck.
Main Outcome Measure
Correlation between c-myc expression and tumor size, nodal involvement, clinical disease stage, and degree of differentiation. Hypothesis formulated after data collection.
Results
Significant negative correlation between the c-myc levels and the number of metastatic nodes (P=.0001) and clinical stage of disease (P=.05). No correlation with tumor size or degree of differentiation.
Conclusions
Reduction or loss of c-myc oncoprotein might be associated with metastatic lymph node involvement and advanced stages of squamous cell carcinoma of the head and neck. Further studies are needed to substantiate preliminary findings.
(Arch Otolaryngol Head Neck Surg. 1994;120:255-259)
Author Affiliations
From the Departments of Otolaryngology–Head and Neck Surgery (Drs Gapany, Pavelic, Kelley, Craven, and Gluckman and Mss Pavelic and Gapany) and Anatomy and Cell Biology (Dr Stambrook), College of Medicine, University of Cincinnati, Ohio.
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