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Thomas M. Price, MD; Thomas C. Allen, PhD; Darrell L. Bowyer, MD; Theodore A. Watson, MD

Arch Otolaryngol Head Neck Surg. 1994;120(2):209-211.

Abstract
Symptoms of Meniere's disease in women may be exacerbated during the luteal phase of the menstrual cycle. This suggests a role for progesterone production and subsequent fluid redistribution as a predisposing factor for Meniere's symptoms. We report the use of leuprolide acetate, a gonadotropin-releasing hormone agonist, in a woman with cyclic Meniere's symptoms. This drug, which abolishes gonadotropin-dependent ovarian sex steroid production, alleviated the patient's symptoms during therapy. This observation offers further support to the hypothesis of sex hormone–related exacerbations of Meniere's symptoms and provides a possible future treatment option for this debilitating disease.

(Arch Otolaryngol Head Neck Surg. 1994;120:209-211)

Author Affiliations
From the Department of Obstetrics and Gynecology, Greenville Hospital System, Reproductive Laboratory Associates, and Piedmont Ear, Nose, and Throat, Greenville, SC.

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