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Deborah J. Doyle, MD; Lee A. Henderson, PhD; Francis E. LeJeune, Jr, MD; Robert H. Miller, MD

Arch Otolaryngol Head Neck Surg. 1994;120(11):1273-1276.

Abstract
A patient with recurrent respiratory papillomatosis progressed spontaneously to carcinoma resulting in death. Serial biopsy specimens obtained during a 9-year course of this patient's disease were tested via polymerase-chain reaction and Southern hybridization to detect the human papillomavirus (HPV) types present during the patient's course of disease. Early biopsy specimens were positive for HPV types 6 and 11. As atypia progressed to carcinoma, HPV types 6 and 11 remained present, but the signal decreased and HPV 16 became increasingly positive. The significance of these findings will be discussed.

(Arch Otolaryngol Head Neck Surg. 1994;120:1273-1276)

Author Affiliations
From the Departments of Otolaryngology–Head and Neck Surgery (Drs Doyle, Henderson, and Miller) and Pathology (Dr Henderson), Tulane Medical School, and the Alton Ochsner Foundation Hospital (Dr LeJeune), New Orleans, La. Dr Henderson is now with the Guthrie Research Institute, Sayre, Pa.

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