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The UCLA Experience 1955 Through 1990

Rufus J. Mark, MD; Luu M. Tran, MD; Joel Sercarz, MD; Yao S. Fu, MD; Thomas C. Calcaterra, MD; Guy F. Juillard, MD

Arch Otolaryngol Head Neck Surg. 1993;119(9):973-978.

Abstract
Between 1955 and 1990, 28 patients with angiosarcoma of the head and neck were seen at UCLA Medical Center, Los Angeles, Calif. Half the lesions arose on the scalp; the remainder occurred in the soft tissues of the face and neck. Nine patients presented with multifocal disease. Follow-up ranged from 3 to 159 months, with a median of 32 months. The overall prognosis was poor, with a 5-year disease-free survival of 26% (7/27 patients). Of 21 patients having recurrences after primary treatment, 90% (19/21 patients) had a component of local failure. Distant metastasis had developed in nine patients at last follow-up. Of patients treated initally with surgery alone, 8% (1/12 patients) remain disease free vs 67% (4/6 patients) who received postoperative radiation therapy, with or without chemotherapy. Only one (14%) of seven patients treated primarily with radiation therapy with or without chemotherapy was rendered disease free. Angiosarcoma usually presents with high-grade histologic features and frequently with multifocal disease. There is propensity for both local recurrence and distant metastasis. Our results and a review of the literature suggest that combined modality therapy offers the best chance for long-term control in patients with angiosarcoma of the head and neck.

(Arch Otolaryngol Head Neck Surg. 1993;119:973-978)

Author Affiliations
From the Radiation Medical Group (Dr Mark), San Diego, Calif, and the Departments of Radiation Oncology (Drs Tran and Juillard), Surgery, Division of Head and Neck (Drs Sercarz and Calcaterra), and Pathology (Dr Fu), UCLA Medical Center, Los Angeles, Calif.

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