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Linda Brodsky, MD; R. James Koch, MD

Arch Otolaryngol Head Neck Surg. 1993;119(8):821-829.

Abstract
• Adenoid physiology as reflected in the qualitative and quantitative bacteriology and immune cell distribution was correlated with clinical presentation in 69 children (16 to 130 months of age) undergoing adenoidectomy for obstructive adenoid hyperplasia (n=38) or chronic adenoid infection (n=31) and in 16 adenoid core biopsy specimens from 16 nondiseased controls. In the control adenoids, few potentially pathogenic bacteria were found as the dominant bacteria in the adenoid core (25%), and significantly greater concentrations of nonpathogens (commensals) were isolated (P<.01). Potential pathogens as the dominant bacteria were found twice as often in obstructive adenoid hyperplasia (62%) and in chronic adenoid infection (55%) (P<.05). Haemophilus influenzae was most common in the diseased adenoids, 53% in obstructive adenoid hyperplasia and 48% in chronic adenoid infection, compared with only 19% in the controls (P<.05). No significant differences in lymphocyte density, B and T cells, as well as T-helper subsets, were found between clinical classifications. However, T-suppressor cells, monocytes-macrophages, and natural killer cells were significantly increased in chronic adenoid infection only (P<.05). The findings in this study support roles for both alterations in bacterial homeostasis and an altered immune profile in the etiology of chronic adenoid disease in children.

(Arch Otolaryngol Head Neck Surg. 1993;119:821-829)

Author Affiliations
From the Departments of Otolaryngology (Drs Brodsky and Koch) and Pediatrics (Dr Brodsky), State University of New York at Buffalo, School of Medicine and Biomedical Sciences, and the Children's Hospital of Buffalo.

Footnotes
Accepted for publication February 8, 1993.

Presented at the Annual Meeting of the American Society of Pediatric Otolaryngology, Palm Desert, Calif, April 13, 1992, and presented as part of the candidate's (L.B.) thesis for the Triological Society, East Greenville, Pa; 1991.

Reprint requests to Children's Hospital of Buffalo, 219 Bryant St, Buffalo, NY 14222 (Dr Brodsky).

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