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Morphologic Development of Experimental Cholesteatoma
Björn Åberg, MD;
Staffan Edström, MD, PhD;
Dan Bagger-Sjöbäck, MD, PhD;
Lars-Gunnar Kindblom, MD, PhD
Arch Otolaryngol Head Neck Surg. 1993;119(3):272-275.
Abstract
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• Using light microscopy, we studied the morphologic events of cholesteatoma progression 8 months after ligation of the ear canal in 14 Mongolian gerbils. Although we observed a wide range of progression, four stages of morphologic development could be clearly distinguished among the 28 specimens: stage I, an orthokeratotic plug in the ear canal without tympanic membrane involvement; stage II, partial retraction of the tympanic membrane; stage III, the interface between cholesteatoma encapsulated within the tympanic membrane and mucosal membranes covering the promontorial wall of the middle-ear cavity was characterized by a buildup of granulation tissue with prominent macrophage infiltration; and stage IV, bone destruction. Chronic inflammation was observed in some but not all stage II to IV cases. Our results indicate that hyperkeratosis is a primary event in cholesteatoma development, that the development of the granulation tissue with activated macrophages may be responsible for the bone destruction, and that acute or chronic inflammation is not a prerequisite for the development of cholesteatoma or the bone resorptive process.
(Arch Otolaryngol Head Neck Surg. 1993;119:272-275)
Author Affiliations
From the Departments of Otorhinolaryngology (Drs Åberg and Edström) and Pathology (Dr Kindblom), University of Göteborg, Sweden, and the Department of Otorhinolaryngology, University of Stockholm (Sweden) (Dr Bagger-Sjöbäck).
Footnotes
Accepted for publication July 16, 1992.
Reprint requests to the ENT Department, Sahlgrenska Sjukhuset, S413 45 Göteborg, Sweden (Dr Edström).
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