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Sandra E. Noble-Topham, MSc; Dan M. Fliss, MD; R. Warren J. Hartwick, MD, FRCPC; C. Margaret McLachlin, MD, FRCPC; Jeremy L. Freeman, MD, FRCSC; Arnold M. Noyek, MD, FRCSC; Irene L. Andrulis, PhD

Arch Otolaryngol Head Neck Surg. 1993;119(12):1299-1304.

Abstract
Objective
This study examined the prevalence and types of human papillomavirus (HPV) DNA in oral cavity verrucous carcinoma.

Design
This was of a retrospective screening study. Formalin-fixed, paraffin-embedded tissue samples were examined by the polymerase chain reaction using DNA primers specific for HPV types 6b/11, 16, and 18.

Setting
The majority of patients were seen at referral centers in Ontario, Canada.

Patients
This study examined 29 oral cavity verrucous carcinomas occurring in a sample of 25 patients from four institutions between 1966 and 1992. All tumors met standardized histologic diagnostic criteria of verrucous carcinoma.

Main Outcome Measure
The prevalence of HPV 6b/11, 16, and 18 DNA was determined by the PCR technique.

Results
The HPV DNA was detected in 12 (48%) of 25 patients. The HPV 6b/11 DNA, HPV 16 DNA, HPV 18 DNA, and HPV 16 DNA plus HPV 18 DNA, were detected in one (4%), one (4%), nine (36%), and one (4%) cases, respectively.

Conclusions
The detection of HPV 18 DNA in 40% of oral cavity verrucous carcinomas suggests an association between the presence of HPV 18 DNA and some oral cavity verrucous carcinomas. The etiologic and prognostic significance of HPV 18 for oral cavity verrucous carcinoma remains unanswered and will require further study.

(Arch Otolaryngol Head Neck Surg. 1993;119:1299-1304)

Author Affiliations
From the Departments of Pathology (Ms Noble-Topham and Drs Hartwick, McLachlin, and Andrulis) and Otolaryngology (Drs Fliss, Freeman, and Noyek), and the Samuel Lunenfeld Research Institute, Mount Sinai Hospital, and the Department of Molecular and Medical Genetics, University of Toronto (Ontario) (Dr Andrulis).

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