 |
|
Chromosome 11Q13 Amplification in Head and Neck Squamous Cell Carcinoma
Michael E. Williams, MD;
Michael J. Gaffey, MD;
Lawrence M. Weiss, MD;
Sharon P. Wilczynski, MD, PhD;
Ed Schuuring, PhD;
Paul A. Levine, MD
Arch Otolaryngol Head Neck Surg. 1993;119(11):1238-1243.
Abstract
| |
Objective
To establish the frequency and clinicopathologic correlates of 11q13 amplification in head and neck squamous cell carcinoma.
Design
Retrospective clinicopathologic analysis.
Setting
University and private cancer centers.
Patients
Eighty-five patients with pathologically confirmed head and neck squamous cell carcinoma.
Measurements
The degree of DNA amplification in each tumor was determined using chromosome 11q13 probes for the bcl-1 major translocation cluster, PRAD1/cyclin D1 (CCND1), the fibroblast growth factor gene HST1, EMS1, and glutathione S transferase, pi-1. The presence or absence of amplification was correlated with anatomic site, tumor stage, cytologic grade, histologic pattern, and mitotic activity.
Results
Thirty-one patients (36%) showed a twofold to 10-fold amplification of 11q13 loci compared with the chromosome 11q23 ETS1 control probe. Twentynine of these encompassed bcl-1 through EMS1 loci; one sample showed only bcl-1 and PRAD1/cyclin D1 plus HST1 amplification, with another amplified at HST1 and EMS1 with minimal or no bcl-1 and PRAD1/cyclin D1 amplification. Amplification was significantly correlated with high cytologic grade, a diffusely infiltrative growth pattern, and with a hypopharyngeal primary site.
Conclusions
Chromosome 11q13 amplification in head and neck squamous cell carcinoma is correlated with an aggressive histologic appearance and hypopharyngeal primary site and should be assessed in prospective clinical trials to determine its utility for treatment stratification and prognosis. Although PRAD 1/cyclin D1 and EMS1 have been implicated in the pathogenesis of neoplasms with 11q13 amplification, rare cases with more limited amplicon size suggest that another relevant gene or genes may exist between these loci.
(Arch Otolaryngol Head Neck Surg. 1993;119:1238-1243)
Author Affiliations
From the Departments of Internal Medicine and Pathology (Drs Williams and Gaffey) and Otolaryngology—Head and Neck Surgery (Dr Levine), University of Virginia School of Medicine, Charlottesville; the Department of Pathology (Drs Weiss and Wilczynski), City of Hope National Medical Center, Duarte, Calif; and the Department of Pathology, University of Leiden, the Netherlands (Dr Schuuring).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Amplicon Mapping and Expression Profiling Identify the Fas-Associated Death Domain Gene as a New Driver in the 11q13.3 Amplicon in Laryngeal/Pharyngeal Cancer
Gibcus et al.
Clin. Cancer Res. 2007;13:6257-6266.
ABSTRACT
| FULL TEXT
Cortactin Overexpression Regulates Actin-Related Protein 2/3 Complex Activity, Motility, and Invasion in Carcinomas with Chromosome 11q13 Amplification
Rothschild et al.
Cancer Res. 2006;66:8017-8025.
ABSTRACT
| FULL TEXT
Glutathione S-Transferase {pi} Amplification is Associated with Cisplatin Resistance in Head and Neck Squamous Cell Carcinoma Cell Lines and Primary Tumors
Cullen et al.
Cancer Res. 2003;63:8097-8102.
ABSTRACT
| FULL TEXT
The Gene Ratios c-MYC:Cyclin-dependent Kinase (CDK)N2A and CCND1:CDKN2A Correlate with Poor Prognosis in Squamous Cell Carcinoma of the Head and Neck
Akervall et al.
Clin. Cancer Res. 2003;9:1750-1755.
ABSTRACT
| FULL TEXT
Markers for Assessment of Nodal Metastasis in Laryngeal Carcinoma
Takes et al.
Arch Otolaryngol Head Neck Surg 1997;123:412-419.
ABSTRACT
MYC Amplification in Squamous Cell Carcinomas of the Head and Neck
Rodrigo et al.
Arch Otolaryngol Head Neck Surg 1996;122:504-507.
ABSTRACT
Chromosome 11q13 Amplification in Head and Neck Squamous Cell Carcinoma: Association With Poor Prognosis
Meredith et al.
Arch Otolaryngol Head Neck Surg 1995;121:790-794.
ABSTRACT
Somatic Gene Therapy in Otolaryngology--Head and Neck Surgery
O'Malley and Ledley
Arch Otolaryngol Head Neck Surg 1993;119:1191-1197.
ABSTRACT
|
