This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Methods for the Present and Future

Bert W. O'Malley, Jr, MD; Fred D. Ledley, MD

Arch Otolaryngol Head Neck Surg. 1993;119(10):1100-1107.

Abstract
Somatic gene therapy involves the introduction of novel genetic material into somatic cells to express therapeutic gene products. This emerging technology holds great promise for the treatment of both inherited and acquired diseases. This review summarizes the principles of gene therapy and approaches that are being investigated in experimental animals and clinical trials. These include the construction of recombinant viruses capable of carrying genes into cells by the process of infection as well as the use of DNA molecules that are capable of being used like conventional medicines. Some methods for gene therapy lead to permanent insertion of genes into targeted cells, while others are designed to express a therapeutic product with a defined half-life and duration of action. The goal is to establish site-specific and regulated expression of therapeutic products. The demonstrated safety and public acceptance of initial clinical trials will lead to widespread investigation of applications in both medicine and surgery in the near future.

(Arch Otolaryngol Head Neck Surg. 1993;119:1100-1107)

Author Affiliations
From the Departments of Otorhinolaryngology (Dr O'Malley), Cell Biology (Dr Ledley), and Pediatrics (Dr Ledley), Baylor College of Medicine, Houston, Tex.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Human Insulinlike Growth Factor 1 Gene Transfer Into Paralyzed Rat Larynx: Single vs Multiple Injection
Shiotani et al.
Arch Otolaryngol Head Neck Surg 1999;125:555-560.
ABSTRACT | FULL TEXT  

IGF-1 Gene Transfer Into Denervated Rat Laryngeal Muscle
Flint et al.
Arch Otolaryngol Head Neck Surg 1999;125:274-279.
ABSTRACT | FULL TEXT  

Somatic Gene Therapy in Otolaryngology--Head and Neck Surgery
O'Malley and Ledley
Arch Otolaryngol Head Neck Surg 1993;119:1191-1197.
ABSTRACT