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Wataru Nishijima, MD; Shoji Takooda, MD; Nobuhiro Tokita, MD; Shojiro Takayama, MD; Mizuyoshi Sakura, MD

Arch Otolaryngol Head Neck Surg. 1993;119(1):65-68.

Abstract
• The frequency of distant metastases was studied in 112 patients who had squamous cell carcinoma of the head and neck. All of these patients died of the tumor and underwent postmortem examinations. Forty-one (37%) of the 112 patients had distant metastases at the time of death. There was a significant correlation between development of distant metastases and the presence of cervical nodes. Of the patients who had distant metastases, 63% had evidence of tumor in the cervical nodes, whereas 37% of these patients were free of disease in the neck. Patients with residual or recurrent tumors in the cervical nodes had a high risk of distant metastases.

(Arch Otolaryngol Head Neck Surg. 1993;119:65-68)

Author Affiliations
From the Departments of Otolaryngology (Drs Nishijima, Takooda, and Tokita), Pathology (Dr Takayama), and Radiology (Dr Sakura), Saitama (Japan) Cancer Center.

Footnotes
Accepted for publication July 10, 1992.

Reprint requests to Department of Otolaryngology, Saitama Cancer Center, 818 Komuro, Ina, Saitama 362, Japan (Dr Nishijima).

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