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Mark C. Weissler, MD; Susan Melin, MD; Scott L. Sailer, MD; Bahjat F. Qaqish, MD, PhD; Julian G. Rosenman, MD, PhD; Harold C. Pillsbury, III, MD

Arch Otolaryngol Head Neck Surg. 1992;118(8):806-810.

Abstract
• Fifty-eight patients with either advanced or unresectable squamous cell carcinoma of the head and neck were randomly selected to receive either twice daily radiation alone or twice daily radiation plus concomitant chemotherapy with cisplatin and fluorouracil (5-fluorouracil). There was no advantage in survival or time to progression with the addition of chemotherapy to twice daily radiation for patients with advanced resectable cancers. In the group of patients with unresectable cancers, however, there was a statistically significant advantage to the addition of chemotherapy, both in terms of disease-free survival and date to progression.

(Arch Otolaryngol Head Neck Surg. 1992;118:806-810)

Author Affiliations
From the Division of Otolaryngology, Head and Neck Surgery (Drs Weissler and Pillsbury), Division of Oncology (Dr Melin), Department of Radiation Oncology (Drs Sailer and Rosenman), and Department of Biostatistics (Dr Qaqish), University of North Carolina, Chapel Hill.

Footnotes
Accepted for publication March 30, 1992.

Reprint requests to 610 Burnett Womack Bldg, CB 7070, University of North Carolina, Chapel Hill, NC 27599-7070 (Dr Weissler).

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