This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Squamous Cell Carcinoma Antigen, Carcinoembryonic Antigen, Lipid-Associated Sialic Acid, and CA-125

Matthew B. Straka; Robin L. Wagner; Jonas T. Johnson, MD; Kimberly Keane Kachman; David E. Eibling, MD

Arch Otolaryngol Head Neck Surg. 1992;118(8):802-805.

Abstract
• An ideal tumor marker should be sensitive in tumor-bearing patients while having adequate specificity so that controls do not demonstrate the marker. To date, a single circulating marker has not been identified for squamous cell carcinoma of the head and neck. This study evaluates a panel including squamous cell carcinoma radioimmunoassay, lipid-associated sialic acid, carcinoembryonic antigen, and CA-125. In this population of patients with cancer, serum samples from 101 patients and 88 controls were evaluated. The squamous cell carcinoma radioimmunoassay was the most sensitive marker identified (47.5%), while carcinoembryonic antigen level was elevated in 40.6%, lipid-associated sialic acid level in only 16.8%, and CA-125 level in 7.9%. False-positive results were found with all markers, including squamous cell carcinoma radioimmunoassay (18.2%), carcinoembryonic antigen (18.2%), lipid-associated sialic acid (10.2%), and CA-125 (15.9%). Various combinations of markers did not significantly improve either specificity or sensitivity. Available tumor markers are inadequate for diagnostic purposes in patients with squamous cell carcinoma of the head and neck.

(Arch Otolaryngol Head Neck Surg. 1992;118:802-805)

Author Affiliations
From the Department of Otolaryngology, University of Pittsburgh (Pa) School of Medicine, The Eye and Ear Institute of Pittsburgh.

Footnotes
Accepted for publication November 5, 1991.

Reprint requests to Department of Otolaryngology, University of Pittsburgh School of Medicine, The Eye and Ear Institute of Pittsburgh, 203 Lothrop St, Suite 500, Pittsburgh, PA 15213 (Dr Johnson).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

A Reappraisal of the Squamous Cell Carcinoma Antigen as a Tumor Marker in Head and Neck Cancer
Snyderman et al.
Arch Otolaryngol Head Neck Surg 1995;121:1294-1297.
ABSTRACT