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Demonstration of Interleukin 6 in Middle Ear Effusions
Robert F. Yellon, MD;
Gerald Leonard, MD;
Phillip Marucha, DMD;
James Sidman, MD;
Robert Carpenter, MD;
Joseph Burleson, PhD;
James Carlson, MD;
Donald Kreutzer, PhD
Arch Otolaryngol Head Neck Surg. 1992;118(7):745-748.
Abstract
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• In response to infection in the middle ear, inflammatory cells produce cytokines—potent regulators and mediators of the immune response. In an earlier study, we demonstrated that levels of the cytokine interleukin 1 were higher in middle-ear effusions from younger children, while levels of the cytokine tumor necrosis factor were higher in middle-ear effusions from older children and in those requiring tympanostomy on multiple occasions. In this study, we evaluated middle-ear effusions for levels of the cytokine interleukin 6. Activities of interleukin 6 include stimulation of bone erosion and production of antibodies and fever. Using an enzyme-linked immunosorbent assay system, significant levels of interleukin 6 (>0.2 pg/mL) were found in 14 (36%) of 39 middle-ear effusions from 25 children with otitis media with effusion. The mean (±SE) level of interleukin 6 in middle-ear effusions was 173.9± 74.7 pg/mg of total protein. Like interleukin 1, levels of interleukin 6 were higher in younger children. Tumor necrosis factor may be an important regulator of the local immune response in the middle-ear cleft during persistence of otitis media with effusion, while interleukin 1 and interleukin 6 may be important regulators during the early stages of otitis media with effusion.
(Arch Otolaryngol Head Neck Surg. 1992;118:745-748)
Author Affiliations
From the Division of Otolaryngology, Department of Surgery (Drs Yellon, Leonard, Sidman, and Carpenter), Department of Behavioral Sciences (Dr Burleson), and Department of Pathology (Drs Marucha and Kreutzer), University of Connecticut Health Center, Farmington; and Department of Surgery, Stamford (Conn) Hospital (Dr Carlson).
Footnotes
Accepted for publication October 17, 1991.
Presented at the Sixth Annual Meeting of the American Society of Pediatric Otolaryngology, Waikoloa, Hawaii, May 9, 1991.
Reprint requests to Department of Pathology, University of Connecticut Health Center, Farmington, CT 06030 (Dr Kreutzer).
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