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David B. Hom, MD; Girma Assefa, MD

Arch Otolaryngol Head Neck Surg. 1992;118(6):624-628.

Abstract
• Angiogenic growth factors have the potential to accelerate vascularization in soft tissue. This study explored the vascular effects of endothelial cell growth factor (1800 µg/mL) with heparin (7 µg/ml) in gelatin sponge (Gelfoam) in two settings of vascular compromise. On days 2 and 3 ligated skin flaps in the rabbit ear model, peripheral neovascularization, and flap viability were quantitatively documented by digital angiographic analysis and by polar planimetry. The mean flap viability of the treated flaps was two times greater than their controls in the day 2 (N = 24) and day 3 ligation groups (N = 22). The angiograms among the treated flaps in the day 2 ligation group also demonstrated a quantitative increase in vascularization compared with their controls. These results suggest a provocative means for accelerating neovascularization and enhancing viability to vascular compromised skin flaps.

(Arch Otolaryngol Head Neck Surg. 1992;118:624-628)

Author Affiliations
From the Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology—Head and Neck Surgery, University of Minnesota Hospital and Hennepin County Medical Center, Minneapolis.

Footnotes
Accepted for publication December 16, 1991.

Presented at the fall meeting of the American Academy of Facial Plastic and Reconstructive Surgery, Kansas City, Mo, September 28, 1991.

Reprint requests to the Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology—Head and Neck Surgery, Box 396, University of Minnesota Hospital and Clinic, Harvard Street at East River Road, Minneapolis, MN 55455 (Dr Hom).

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