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Robert J. S. Briggs, MBBS, FRACS; Kenneth J. Pienta, MD; Ralph H. Hruban, MD; William J. Richtsmeier, MD, PhD

Arch Otolaryngol Head Neck Surg. 1992;118(5):531-533.

Abstract
• Quantitative morphometric analyses of the nuclear shape have been successfully used with prostatic carcinoma to predict tumor metastatic potential and provide the most sensitive indicator of tumor aggressiveness in the individual case. We have studied the nuclear morphometric characteristics of 22 patients with T1 and T2 squamous cell carcinoma of the floor of the mouth to see if a correlation existed between lack of nuclear roundness and presence of cervical metastatic disease. A significant difference was identified between the morphology of cancer cell nuclei and normal squamous epithelium. Nuclear morphology could not be used to distinguish between patients with cervical node-negative and node-positive disease. Some patients both with and without cervical metastates who are long-term survivors had nuclear roundness scores in the highest range, reflecting greatest variation from normal.

(Arch Otolaryngol Head Neck Surg. 1992;118:531-533)

Author Affiliations
From the Department of Otolaryngology—Head and Neck Surgery (Drs Briggs and Richtsmeier), Oncology Center (Dr Pienta), and Department of Pathology (Dr Hruban), The Johns Hopkins Hospital School of Medicine, Baltimore, Md. Dr Richtsmeier is now with Duke Medical Center, Durham, NC.

Footnotes
Accepted for publication December 30, 1991.

Reprint requests to the Division of Otolaryngology—Head and Neck Surgery, DUMC, Box 3805, Duke Medical Center, Durham, NC 27710 (Dr Richtsmeier).

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