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LCDR Dennis D. Diaz, MC; Stephen B. Freeman, MD; Joseph F. Wilson, MD; CAPT Gregg S. Parker, MC

Arch Otolaryngol Head Neck Surg. 1992;118(5):516-518.

Abstract
• Skin flap necrosis due to underlying hematoma can be devastating in reconstructive surgery. The production of free radicals in ischemic tissue and cellular damage caused by them have been well established. Deferoxamine, which is both an iron chelator and a free radical scavenger may have a dual benefit in the pharmacologic manipulation of necrosis in a flap jeopardized by hematoma. Past studies showing the importance of free radical scavengers in improving flap survival in hematoma-induced flap necrosis have used the rat model. The porcine model was used for this study because it is the animal model that most closely resembles human skin. A statistically significant benefit of deferoxamine in reducing necrosis of a skin flap induced by hematoma formation was found. Deferoxamine appears to be promising but requires further investigation before it can be optimally used in human applications.

(Arch Otolaryngol Head Neck Surg. 1992;118:516-518)

Author Affiliations
USNR; USNR

From the Department of Otolaryngology—Head and Neck Surgery, Naval Hospital, Charleston, SC (Dr Diaz), and Department of Otolaryngology—Head and Neck Surgery, Naval Hospital, Portsmouth, Va (Drs Freeman, Wilson, and Parker). Drs Freeman and Wilson are now in private practice, Indianapolis, Ind, and Newport News, Va, respectively.

Footnotes
Accepted for publication January 10, 1992.

Read before the Pacific Coast Oto-Ophthalmologic Society Meeting, Monterey, Calif, June 18,1991, and the fall meeting of the American Academy of Facial Plastic and Reconstructive Surgery, Kansas City, Mo, September 28, 1991.

The opinions or assertions expressed herein are those of the authors and are not to be construed as official or as reflecting the views of the US Department of the Navy or US Department of Defense.

Reprint requests to the Department of Otolaryngology—Head and Neck Surgery, Naval Hospital, Charleston, SC 29408 (Dr Diaz).

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