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Monica B. Spaulding, MD; Manuel Castillo, MD; John Loré, MD; Honora Heffner

Arch Otolaryngol Head Neck Surg. 1992;118(3):248-251.

Abstract
• We reviewed the results of standard therapy (surgery ± radiation therapy) in 66 patients with advanced resectable head and neck cancer treated between 1984 and 1988 and compared them with a "historical" group of similar resectable patients treated between 1978 and 1984, by induction chemotherapy followed by standard therapy. The median disease-free survival of patients treated by surgery was 18 months, whereas it had not been reached in those receiving chemotherapy. When 2-year disease-free survival was compared according to stage and site, patients receiving chemotherapy fared better. The recurrence rate of all patients receiving chemotherapy was less than half of those receiving standard treatment only. A higher percentage of patients receiving chemotherapy survived their original tumor, only to die of second malignancies, most of these occurring elsewhere in the aerodigestive tract.

(Arch Otolaryngol Head Neck Surg. 1992;118:248-251)

Author Affiliations
From the Veterans Affairs Medical Center (Drs Spaulding and Castillo); Sisters of Charity Hospital (Drs Spaulding and Loré); and State University of New York at Buffalo (Dr Spaulding and Ms Heffner), Buffalo.

Footnotes
Accepted for publication October 14, 1991.

Reprints not available.

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