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Richard L. Goode, MD; Bruce N. Reynolds, MD

Arch Otolaryngol Head Neck Surg. 1992;118(2):201-204.

Abstract
• Reconstruction of the mandible to restore continuity following resection is described in four cases using a tobramycin-impregnated methylmethacrylate implant fabricated at the time of surgery. Methylmethacrylate has excellent biocompatibility and strength and has been used in surgery for over 20 years. The technique uses readily available materials and is similar in concept to reconstruction with a metal plate. Potential advantages are: (1) the presence of a potent antibiotic within the implant that is released over a period of months to minimize postoperative infection and (2) the capability of the material to accurately fit any defect, either when used alone or in combination with a plate or rod. Three of the four patients whom we present are doing well; one implant became exposed following postoperative radiotherapy and had to be removed.

(Arch Otolaryngol Head Neck Surg. 1992;118:201-204)

Author Affiliations
From the Department of Surgery, Stanford (Calif) University Medical Center and the Otolaryngology Section, Palo Alto (Calif) Veterans Affairs Medical Center.

Footnotes
Accepted for publication August 5, 1991.

Presented at the Fall Meeting of the American Academy of Facial Plastic and Reconstructive Surgery, San Diego, Calif, September 7, 1990.

Reprint requests to the Division of Otolaryngology, Stanford University Medical Center, Stanford, CA 94305 (Dr Goode).

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