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Intratumoral DNA Content Heterogeneity in Laryngeal Squamous Cell Carcinoma
Adel K. El-Naggar, MD;
Virginia Lopez-Varela, MD;
Mario A. Luna, MD;
Randal Weber, MD;
John G. Batsakis, MD
Arch Otolaryngol Head Neck Surg. 1992;118(2):169-173.
Abstract
• Multiple tissue samples obtained from sections cut by Michaels and Gregor's method obtained from 21 consecutive total laryngectomies for squamous cell carcinoma were studied for intratumoral DNA content heterogeneity or homogeneity. Concordant DNA ploidy was manifested in all samples of five (23.8%) carcinomas (two diploid and three aneuploid), while 16 carcinomas (76.2%) demonstrated a variable DNA ploidy (diploid and aneuploid). Analysis of cellular proliferative activity demonstrated remarkable intratumoral stability in both concordant and discordant carcinomas. These data indicate there is a considerable heterogeneity of DNA ploidy but the proliferative rate is relatively stable within the carcinomas. Clinical implications of our findings are also presented.
(Arch Otolaryngol Head Neck Surg. 1992;118:169-173)
Author Affiliations
From the Departments of Pathology (Drs El-Naggar, Luna, and Batsakis) and Head and Neck Surgery (Dr Weber), The University of Texas M. D. Anderson Cancer Center, Houston; and the Universidad Autonoma de Guadalajara (Mexico) (Dr Lopez-Varela).
Footnotes
Accepted for publication September 13, 1991.
Presented in part at the 33rd annual meeting of the American Society for Head and Neck Surgery, Waikaloa, Hawaii, May 7-9,1991.
Reprint requests to the Department of Pathology, Box 85, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 (Dr El-Naggar).
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