This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Eugenia Allegra, MD; Aldo Garozzo, MD; Agata Grillo, PhD; Giovanni Battista Catalano, MD

Arch Otolaryngol Head Neck Surg. 1992;118(12):1320-1322.

Abstract
• The purpose of this study was to determine the most frequent chromosomal abnormalities in laryngeal carcinomas. Biopsy specimens of surgical resections from laryngeal squamous cell carcinomas from 15 patients representing different degrees of histologic differentiation were analyzed in short-term culture. Nine of the 15 tumors were hypodiploid with 41 to 45 chromosomes, and four of the 15 tumors were polyploid with more than 50 chromosomes. The most frequent chromosomal alterations we noted included deletion of the short arm of chromosome 3 in 60%, monosomy of chromosome 11 in 30%, and inversions of chromosome 9 and 16 that were present in 20% of the cases.

(Arch Otolaryngol Head Neck Surg. 1992;118:1320-1322)

Author Affiliations
From the Institute of Otorhinolaryngology—University of Catania (Drs Allegra, Garozzo, and Catalano) and the Laboratory of Human Genetics (Dr Grillo), Catania, Italy.

Footnotes
Accepted for publication July 10, 1992.

Reprint requests to Istituto di Otorinolaringoiatria-Universitá di Catania, c/o Ospedale Garibaldi-Piazza S.M. di Gesú, 95123 Catania, Italy (Dr Allegra).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?