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Chap T. Le, PhD; Kathy A. Daly, PhD; Robert H. Margolis, PhD; Bruce R. Lindgren, MS; G. Scott Giebink, MD

Arch Otolaryngol Head Neck Surg. 1992;118(11):1225-1228.

Abstract
• An otitis media with effusion algorithm developed by Paradise et al and tested by Cantekin et al has become the basis for many studies of otitis media. However, a two-point scale algorithm (otitis media with effusion–no otitis media with effusion) may be too ambitious (ie, low specificity) and too optimistic (ie, absence of fluid does not necessarily mean normal ear). We propose a four-point profile that characterizes the condition of the middle ear, and we report the validation of the profile against findings at myringotomy. Statistically, a four-point scale profile would substantially increase powers of statistical tests, compared with a two-point scale algorithm (in studies of the same size), when used to study changes of the middle-ear condition over time or to compare treatment effects.

(Arch Otolaryngol Head Neck Surg. 1992;118:1225-1228)

Author Affiliations
From the Otitis Media Research Center (Drs Le, Daly, Margolis, and Giebink and Mr Lindgren), and the Division of Biostatistics (Dr Le and Mr Lindgren), School of Public Health, and the Departments of Otolaryngology (Drs Daly, Margolis, and Giebink) and Pediatrics (Dr Giebink), School of Medicine, University of Minnesota, Minneapolis.

Footnotes
Accepted for publication June 2, 1992.

Reprint requests to School of Public Health, Box 197 UMHC, University of Minnesota, Minneapolis, MN 55455 (Dr Le).

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