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A Histologic Study of Nonmorphogenetic Forms of Hereditary Hearing Impairment
Richard J. H. Smith, MD;
Karen P. Steel, PhD;
Chris Barkway;
Sava Soucek, MD, PhD;
Leslie Michaels, MD, DPath
Arch Otolaryngol Head Neck Surg. 1992;118(10):1085-1094.
Abstract
It appears that many forms of syndromic and nonsyndromic hereditary hearing impairment are secondary to either neuroepithelial or cochleosaccular dysfunction. Making this distinction can be difficult in human temporal bone specimens; however, this added knowledge may ultimately provide prognostic and therapeutic information in hearing habilitation. Fundamental studies using animal models of different types of hereditary deafness may also prove useful in this respect.
(Arch Otolaryngol Head Neck Surg. 1992;118:1085-1094)
Author Affiliations
From the Department of Otolaryngology—Head and Neck Surgery, The University of Iowa, Iowa City (Dr Smith); Medical Research Council Institute of Hearing Research, University of Nottingham (England) (Dr Steel and Mr Barkway); and Otolaryngology/Audiology Department, St Mary's Hospital (Dr Soucek), and Department of Histopathology, University College and Middlesex School of Medicine (Dr Michaels), London, England.
Footnotes
Accepted for publication May 12, 1992.
Presented at the American Academy of Pediatric Otolaryngology Annual Meeting, Waikoloa, Hawaii, May 9, 1991.
Reprint requests to Department of Otolaryngology, Molecular Otolaryngology Research Laboratories, The University of Iowa, Iowa City, IA 52242 (Dr Smith).
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