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Acute-Phase Proteins in Patients With Head and Neck Cancer Treated With Interleukin 2/Interferon Alfa
Gary L. Clayman, DDS, MD;
Frank J. Liu, MD;
Howard E. Savage, PhD;
Dorothy L. Taylor, MS;
Pierre Lavedan;
Robert M. Buchsbaum, MD;
Candice Pellegrino;
Jose M. Trujillo, MD;
Gregory Young;
Stimson P. Schantz, MD
Arch Otolaryngol Head Neck Surg. 1992;118(1):41-48.
Abstract
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• Circulating acute-phase proteins may mediate adverse reactions in patients receiving biologic response modifiers, including inhibition of immune responsiveness and clinical toxic effects. Nine patients with unresectable head and neck squamous cell carcinoma were prospectively examined for levels of acute-phase proteins during interleukin 2/interferon alfa immunotherapy and for clinical toxic effects. Simultaneous determination of the in vitro immunomodulatory capacity of autologous serum on the induction of lymphokine-activated killer cells was assessed in 4-hour chromium release assays. Of the seven acute-phase proteins analyzed, haptoglobin and C-reactive protein levels were elevated before therapy was started. Toxic events leading to cessation of interleukin 2/interferon alfa therapy had a high correlation with elevated C-reactive protein and lowered C3 component of complement levels. No relationship was noted between serum levels of acute-phase proteins and induction inhibition of lymphokine-activated killer cell cytotoxicity. The role of C-reactive protein and complement degradation products in mediating interleukin 2/interferon alfa toxicity requires further investigation.
(Arch Otolaryngol Head Neck Surg. 1992;118:41-48)
Author Affiliations
From the Departments of Head and Neck Surgery (Drs Clayman, Savage, and Schantz, Mss Taylor and Pellegrino, and Messrs Lavedan and Young) and Laboratory Medicine (Drs Liu, Buchsbaum, and Trujillo), The University of Texas M. D. Anderson Cancer Center, Houston.
Footnotes
Accepted for publication May 9, 1991.
Presented at the 32nd Annual Meeting of The American Society for Head and Neck Surgery, West Palm Beach, Fla, May 1, 1990.
Reprint requests to the Department of Head and Neck Surgery, 1515 Holcombe Blvd, Box 69, Houston, TX 77030 (Dr Clayman).
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