This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Allan L. Abramson, MD; Mark J. Shikowitz, MD; Virginia M. Mullooly, RN, MS; Bettie M. Steinberg, PhD; Carol Ann Amella, MA; Hannah R. Rothstein, PhD

Arch Otolaryngol Head Neck Surg. 1992;118(1):25-29.

Abstract
• Thirty-three patients with moderate to severe recurrent laryngeal papillomatosis underwent photodynamic therapy at our institution. All received 2.5 mg/kg of dihematoporphyrin ether intravenously either 48 or 72 hours prior to photoactivation with an argon pump dye laser system. Photosensitivity was the only side effect seen. Statistical analysis showed a significant decrease, by approximately 50%, in the average rate of laryngeal papilloma growth following treatment. The response was especially pronounced in patients with the worst disease. In addition, three patients have now remained free of disease for extended periods following photodynamic therapy. Latent infection with human papillomavirus continues to persist in clinically normal tissue following photodynamic therapy. The results and potential of this exciting new therapy for laryngeal papillomatosis are described.

(Arch Otolaryngol Head Neck Surg. 1992;118:25-29)

Author Affiliations
From the Department of Otolaryngology and Communicative Disorders, Long Island Jewish Medical Center, New Hyde Park, NY (Drs Abramson, Shikowitz, Steinberg, and Mss Mullooly and Amella); and Baruch College, New York, NY (Dr Rothstein).

Footnotes
Accepted for publication July 17, 1991.

Reprint requests to the Department of Otolaryngology and Communicative Disorders, Long Island Jewish Medical Center, New Hyde Park, NY 11042 (Dr Abramson).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Recurrent Respiratory Papillomatosis in Children: Masquerader of Common Respiratory Diseases
Zacharisen and Conley
Pediatrics 2006;118:1925-1931.
ABSTRACT | FULL TEXT  

Clinical Trial of Photodynamic Therapy With Meso-Tetra (Hydroxyphenyl) Chlorin for Respiratory Papillomatosis
Shikowitz et al.
Arch Otolaryngol Head Neck Surg 2005;131:99-105.
ABSTRACT | FULL TEXT  

Failure of Gamma Interferon but Not Interleukin-10 Expression in Response to Human Papillomavirus Type 11 E6 Protein in Respiratory Papillomatosis
DeVoti et al.
CVI 2004;11:538-547.
ABSTRACT | FULL TEXT  

Intralesional Cidofovir for Recurrent Respiratory Papillomatosis in Children
Pransky et al.
Arch Otolaryngol Head Neck Surg 1999;125:1143-1148.
ABSTRACT | FULL TEXT  

Photodynamic Therapy Using m-Tetra(Hydroxyphenyl) Chlorin: An Animal Model
Lofgren et al.
Arch Otolaryngol Head Neck Surg 1994;120:1355-1362.
ABSTRACT  

Variable Light-Dose Effect on Photodynamic Therapy for Laryngeal Papillomas
Abramson et al.
Arch Otolaryngol Head Neck Surg 1994;120:852-855.
ABSTRACT  

Photodynamic Therapy in Dermatology: Shedding a Different Light on Skin Disease
Lui and Anderson
Arch Dermatol 1992;128:1631-1636.
ABSTRACT  

Otolaryngology--Head and Neck Surgery
Bailey
JAMA 1992;268:395-397.
ABSTRACT