This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

I. Changes in Adolescent SHR/N-cp Rats

Rudolph J. Triana, MD; Gregg W. Suits, MD; Scott Garrison; Jiri Prazma, MD, PhD; P. Bradley Brechtelsbauer; Otho E. Michaelis, PhD; Harold C. Pillsbury, MD

Arch Otolaryngol Head Neck Surg. 1991;117(6):635-640.

Abstract
• The association between diabetes mellitus and hearing impairment has been debated in many previous studies. The spontaneous hypertensive/NIH-corpulent (SHR/N-cp) rat has been shown to be a unique genetic model for non—insulin-dependent diabetes mellitus. Seventeen diabetic and 17 control young male rats were divided into groups according to diet and phenotype. The rats were fed either 54% of sucrose or 54% starch diets for 3.5 months and killed at 5 months. The cochleas were fixed, decalcified, dissected, and stained for hair cell counting. A significant loss of outer hair cells was noted in the diabetic obese (SHR/N-cp) animals when compared with the control obese (LA/N-cp) animals in every group. Although no significant difference was noted between the diabetic obese (SHR/N-cp) animals receiving the starch and sugar diets, the diabetic obese (SHR/N-cp) animals were more severely affected than the nondiabetic lean (SHR/N-cp) rats.

(Arch Otolaryngol Head Neck Surg. 1991; 117:635-640)

Author Affiliations
From the Division of Otolaryngology/Head and Neck Surgery, University of North Carolina School of Medicine, Chapel Hill (Drs Triana, Suits, Prazma, and Pillsbury, and Messrs Garrison and Brechtelsbauer); and the Beltsville (Md) Human Nutrition Research Center, Agriculture Research Service, US Department of Agriculture (Dr Michaelis).

Footnotes
Accepted for publication December 3, 1990.

Reprint requests to Otolaryngology/Head and Neck Surgery, 610 Burnett Womack Bldg, CB 7070, Chapel Hill, NC 27599-7070 (Dr Prazma).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Inner Ear Damage Secondary to Diabetes Mellitus: II. Changes in Aging SHR/N-cp Rats
Rust et al.
Arch Otolaryngol Head Neck Surg 1992;118:397-400.
ABSTRACT