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Circulating C1q-Binding Macromolecules and Their Relationship to Radiographic Characteristics of Laryngeal Cancer
Pierre Lavedan;
Howard E. Savage, PhD;
Ya-Yen Lee, MD;
Gregory Young;
Stimson P. Schantz, MD
Arch Otolaryngol Head Neck Surg. 1991;117(3):292-296.
Abstract
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• Circulating macromolecules capable of binding the first component of complement (C1qBM) may represent subcellular components of tissue/tumor debris generated from rapidly proliferating invasive disease. Thirty-eight patients were randomly selected from 74 untreated patients with laryngeal cancer on the basis of disease stage and C1qBM levels. C1qBM levels were correlated with computed tomographic evidence of tumor necrosis and/or thyroid cartilage destruction. Results show that patients with stage III/IV disease with tissue necrosis and/or cartilage invasion had demonstrably higher C1qBM levels than did individuals with similarly staged disease with no evidence of these radiographically defined characteristics (120 ± 81 µg/mL vs 18 ± 15 µg/mL); the strongest association was reflected by the area of necrosis within regional lymph metastases. Elevated C1 qBM level in patients with stage III/IV laryngeal cancer thus reflects highly aggressive disease, which is less responsive to therapeutic intervention.
(Arch Otolaryngol Head Neck Surg. 1991;117:292-296)
Author Affiliations
From the Departments of Head and Neck Surgery (Messrs Lavedan and Young and Drs Savage and Schantz) and Radiology (Dr Lee), The University of Texas M. D. Anderson Cancer Center, Houston.
Footnotes
Accepted for publication October 1, 1990.
Reprint requests to Department of Head and Neck Surgery, Box 69, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 (Dr Schantz).
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