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Ulrich Specks, MD; Thomas V. Colby, MD; Kerry D. Olsen, MD; Richard A. DeRemee, MD

Arch Otolaryngol Head Neck Surg. 1991;117(2):218-223.

Abstract
• Salivary gland involvement is a rare clinical feature of Wegener's granulomatosis. We report a series of five cases in which submandibular or parotid gland swelling was part of the initial manifestation of the disease. All patients had limited forms of Wegener's granulomatosis. The value of determination of serum anti-neutrophil cytoplasmic autoantibodies is demonstrated in four of the cases, and its use as a new diagnostic adjunct and promising tool to monitor disease activity is discussed. The use of trimethoprim-sulfamethoxazole as part of alternative treatment regimens for limited Wegener's granulomatosis is advocated.

(Arch Otolaryngol Head Neck Surg. 1991;117:218-223)

Author Affiliations
From the Divisions of Thoracic Diseases, Department of Internal Medicine (Drs Specks and DeRemee), Pathology, Department of Laboratory Medicine and Pathology (Dr Colby), and the Department of Otorhinolaryngology (Dr Olsen), Mayo Clinic and Foundation, Rochester, Minn.

Footnotes
Accepted for publication July 31, 1990.

Reprint requests to Division of Thoracic Diseases, Department of Internal Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905 (Dr DeRemee).

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