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Adverse Histologic Factors and Therapeutic Implications

Randal S. Weber, MD; Robert M. Byers, MD; Brian Petit, MD; Patricia Wolf; Kian Ang, MD; Mario Luna, MD

Arch Otolaryngol Head Neck Surg. 1990;116(9):1055-1060.

Abstract
• We reviewed our 41-year experience with tumors of the submandibular gland to determine what factors influence outcome and their implications for treatment. The most common benign neoplasm was pleomorphic adenoma (21), while among malignant tumors the adenoid cystic variety (37) predominated. For the 86 patients who had malignant tumors, the 2- and 5-year survivals by the life table method were 82% and 69%, respectively. For patients with malignant tumors, histology, size, perineural invasion, and prior treatment did not affect overall survival. Factors adversely affecting outcome were extraglandular soft-tissue extension and lymph node metastasis. Local-regional control was enhanced in patients with soft-tissue extension if they were treated by surgery followed by radiotherapy rather than by surgery alone.

(Arch Otolaryngol Head Neck Surg. 1990;116:1055-1060)

Author Affiliations
From the Department of Head and Neck Surgery (Drs Weber, Byers, and Petit and Ms Wolf), Division of Radiotherapy (Dr Ang), and the Division of Pathology (Dr Luna), The University of Texas M. D. Anderson Cancer Center, Houston.

Footnotes
Accepted for publication May 15, 1990.

Reprint requests to the Department of Head and Neck Surgery, 1515 Holcombe Blvd, Box 69, Houston, TX 77030 (Dr Weber).

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