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In Search of Cochlear Morphologic Correlates for Tinnitus
Carlos A. Oliveira, MD, PhD;
Harold F. Schuknecht, MD;
Robert J. Glynn, PhD, ScD
Arch Otolaryngol Head Neck Surg. 1990;116(8):937-939.
Abstract
• A correlative study was made of the cochlear pathologic features existing in the temporal bones of 83 subjects with a clinical history of tinnitus and 33 without tinnitus. None of 24 types of pathologic change assessed by light microscope occurred in more than 40% of tinnitus cases; nor was the prevalence of any of these pathologic changes significantly greater in subjects with tinnitus compared with control subjects. For five types of morphologic alteration the prevalence was significantly greater among control subjects compared with tinnitus cases, but this is interpreted cautiously because of the challenge in retrospectively selecting an appropriate control group. Under the conditions of the study, that is, using light-microscopic techniques on tissues obtained post mortem, we could not identify a pathologic correlate for tinnitus.
(Arch Otolaryngol Head Neck Surg. 1990;116:937-939)
Author Affiliations
From the Departments of Otology and Laryngology (Drs Oliveira and Schuknecht), and Ophthalmology (Dr Glynn), Harvard Medical School; and Department of Otolaryngology (Drs Oliveira and Schuknecht) and Epidemiology Unit (Dr Glynn), Massachusetts Eye and Ear Infirmary, Boston, Mass.
Footnotes
Accepted for publication April 24, 1990.
Reprint requests to the Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, MA 02114 (Dr Schuknecht).
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