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Nobuo Matsumoto, MD; Hitoshi Saito, MD; Norio Miyoshi, PhD; Kazuo Nakanishi, MD; Masaru Fukuda, MD

Arch Otolaryngol Head Neck Surg. 1990;116(7):824-829.

Abstract
• We investigated the time course of hematoporphyrin oligomer uptake in squamous cell carcinoma transplanted into C3H mice after intraperitoneal injection by measuring its fluorescence intensity. The intensity peaked 83 hours after the injection. The tumors disappeared after an average of 4.12 days with a single application of photodynamic therapy or microwave hyperthermia 83 hours after hematoporphyrin oligomer injection. However, all the tumors treated with these single modalities regrew within 4 weeks after the treatments. Therefore, we investigated the therapeutic effect of microwave hyperthermia in combination with photodynamic therapy. As a result, the combination effect was strongest when high-dose therapy was used as the first choice, irrespective of the order of the treatments, and no tumor regrowth occurred for 45 days.

(Arch Otolaryngol Head Neck Surg. 1990;116:824-829)

Author Affiliations
From the Departments of Otolaryngology (Drs Matsumoto and Saito) and Pathology (Drs Miyoshi, Nakanishi, and Fukuda), Fukui (Japan) Medical School.

Footnotes
Accepted for publication December 1, 1989.

Presented at the Second Japan-Korea Joint Meeting of Otorhinolaryngology—Head and Neck Surgery, Osaka, Japan, May 24, 1988, and at the Fifth International Symposium on Hyperthermic Oncology, Kyoto, Japan, September 3, 1988.

Reprint requests to the Department of Otolaryngology, Fukui Medical School, Yoshida-gun, Fukui 910-11, Japan (Dr Matsumoto).

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