 |
|
Prevention of Microvascular Thrombosis With Controlled-Release Transmural Heparin
Nicholas S. Jones, BDS, FRCS;
Michael G. Glenn, MD;
Lisa A. Orloff, MD;
Marc R. Mayberg, MD
Arch Otolaryngol Head Neck Surg. 1990;116(7):779-785.
Abstract
• The use of controlled local-release heparin was studied as a means to prevent thrombosis in microvascular surgery, using a rat arterial inversion graft as a model. Polyvinyl alcohol embedded with heparin was placed around the outside of inversion graft anastomoses in 16 animals. Results were compared with control group animals in which polyvinyl alcohol alone was placed around the graft or systemic heparin was given. Vessel patency rates were significantly higher for animals receiving either systemic or transmural heparin than for animals in the control group. Controlled local delivery of heparin did not cause measurable systemic anticoagulation. However, the complication of local hematoma formation occurred as frequently as in the systemic heparin group. Controlled transmural release of heparin has an effective local antithrombotic effect and may hold promise for use in clinical practice.
(Arch Otolaryngol Head Neck Surg. 1990:116:779-785)
Author Affiliations
From Guy's Hospital, London, England (Dr Jones), and the Departments of Otolaryngology-Head and Neck Surgery (Drs Jones, Glenn, and Orloff) and Neurosurgery (Dr Mayberg), University of Washington, Seattle.
Footnotes
Accepted for publication April 24, 1990.
Read before the Spring Meeting of the American Society for Head and Neck Surgery, Palm Beach, Fla, April 30, 1990.
Reprint requests to Department of Otolaryngology-Head and Neck Surgery, University of Washington RL-30, Seattle, WA 98195 (Dr Glenn).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Inhibitors of Nitric Oxide Promote Microvascular Thrombosis
Azizzadeh et al.
Arch Facial Plast Surg 2003;5:31-35.
ABSTRACT
| FULL TEXT
|
