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Flint A. Boettcher, PhD; Brian R. Bancroft, MA; Richard J. Salvi, PhD

Arch Otolaryngol Head Neck Surg. 1990;116(6):681-684.

Abstract
• The concentration of salicylate in serum and perilymph was measured in chinchillas after intraperitoneal administration of sodium salicylate. Serum salicylate concentration peaked 2 to 4 hours after a single injection. Clearance was approximately complete after 16 hours. The within-subject variability of serum concentration 4 hours after injection was very low. Subject weight significantly affected serum salicylate concentration, with heavier animals showing higher serum levels. The relationship of perilymph to serum salicylate concentration was approximately linear, with a high correlation between measures.

(Arch Otolaryngol Head Neck Surg. 1990;116:681-684)

Author Affiliations
From the Hearing Research Laboratory, Department of Communicative Disorders and Sciences, State University of New York at Buffalo.

Footnotes
Accepted for publication February 5, 1990.

Reprint requests to Hearing Research Laboratory, 215 Parker Hall, State University of New York at Buffalo, Buffalo, NY 14214 (Dr Boettcher).

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