 |
|
Demineralized BoneImplant Resorption With Long-term Follow-up
Dean M. Toriumi, MD;
Wayne F. Larrabee, Jr, MD;
Joseph W. Walike, MD;
Donna J. Millay, MD;
David W. Eisele, MD
Arch Otolaryngol Head Neck Surg. 1990;116(6):676-680.
Abstract
| |
• The osteoinductive properties of demineralized bone have stimulated its use in facial skeletal augmentation and reconstruction. Demineralized bone has been shown to induce phenotypic conversion of mesenchymal cells into osteoblasts, with bone formation within 29 days (osteoinduction). In this clinical study, 75 demineralized bone implants were followed up from 1 to 48 months (average follow-up, 14.3 months). There were 41 major dorsal implants, with an average degree of resorption of 50.7%. Eight dorsal implants were followed up for more than 24 months, with an 82.5% degree of resorption. Overall resorption for all implants was 49%. Major factors contributing to implant resorption included lack of surrounding mesenchymal cells and inadequate contact between host tissue and bone-inducing surface area. Other factors included infection, poor vascularity, and compression of the implant. Demineralized bone has an unacceptably high resorption rate and should only be used in highly selective cases where the implant can be positioned in a site rich in primitive mesenchymal or bone-forming cells.
(Arch Otolaryngol Head Neck Surg. 1990;116:676-680)
Author Affiliations
From the Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology—Head and Neck Surgery, Eye and Ear Infirmary, University of Illinois at Chicago (Dr Toriumi); the Department of Otolaryngology, University of Vermont College of Medicine, Burlington (Dr Millay); and the Department of Otolaryngology—Head and Neck Surgery, The Johns Hopkins School of Medicine, Baltimore, Md (Dr Eisele). Drs Larrabee and Walike are in private practice, Seattle, Wash.
Footnotes
Accepted for publication February 18, 1990.
Presented in part at the Fifth International Symposium on Plastic and Reconstructive Surgery of the Head and Neck, Toronto, Canada, June 28, 1989.
Reprint requests to Division of Facial Plastic and Reconstructive Surgery (m/c 648), University of Illinois at Chicago, Eye and Ear Infirmary, 1855 W Taylor St, Chicago, IL 60612 (Dr Toriumi).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Perichondrium-Wrapped Collagenous Matrices to Induce Chondroneogenesis: An In Vitro Study
van Lange et al.
Arch Facial Plast Surg 2001;3:122-126.
ABSTRACT
| FULL TEXT
Insulinlike Growth Factor 1- and 2-Augmented Collagen Gel Repair of Facial Osseous Defects
Toung et al.
Arch Otolaryngol Head Neck Surg 1999;125:451-455.
ABSTRACT
| FULL TEXT
Osteoinduction Using Bone Morphogenic Protein in Irradiated Tissue
Howard et al.
Arch Otolaryngol Head Neck Surg 1998;124:985-988.
ABSTRACT
| FULL TEXT
Tracheal Autograft Prefabrication Using Microfibrillar Collagen and Bone Morphogenetic Protein
Kuriloff and Fayad
Arch Otolaryngol Head Neck Surg 1996;122:1385-1389.
ABSTRACT
Nasal Reconstruction Using an Osteoconductive Collagen Gel Matrix
Lindsey et al.
Arch Otolaryngol Head Neck Surg 1996;122:37-40.
ABSTRACT
Ethmoid Bone Sandwich Grafting for Caudal Septal Defects
Metzinger et al.
Arch Otolaryngol Head Neck Surg 1994;120:1121-1125.
ABSTRACT
Facial Skeletal Augmentation Using Hydroxyapatite Cement
Shindo et al.
Arch Otolaryngol Head Neck Surg 1993;119:185-190.
ABSTRACT
Irradiated Cartilage Grafts in the Nose: A Preliminary Report
Kridel and Konior
Arch Otolaryngol Head Neck Surg 1993;119:24-31.
ABSTRACT
Mandibular Reconstruction With a Recombinant Bone-Inducing Factor: Functional, Histologic, and Biomechanical Evaluation
Toriumi et al.
Arch Otolaryngol Head Neck Surg 1991;117:1101-1112.
ABSTRACT
|
