This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Benjamin Finkelhor Asher, MD; Trevor J. I. McGill, MD; Lawrence Kaplan, MD; Ellen M. Friedman, MD; Gerald B. Healy, MD

Arch Otolaryngol Head Neck Surg. 1990;116(5):594-595.

Abstract
• The association between catastrophic airway events and developmental delay was examined in patients with CHARGE (coloboma, heart disease, atresia choanae, retarded growth and/or development, genital hypoplasia, and ear anomalies and/or deafness) association. A retrospective chart analysis was performed from The Children's Hospital in Boston, Mass. Sixteen patients were identified with CHARGE association. Nine patients had at least one respiratory arrest, and 7 had no airway difficulties. Some degree of developmental delay was seen in 14 patients, but was most severe in those patients who suffered a respiratory arrest. We conclude that children with CHARGE association have a propensity for airway instability and that cerebral hypoxia contributed to the developmental delay in some of our patients. We recommend early tracheotomy rather than early choanal atresia repair in these patients to protect the central nervous system.

(Arch Otolaryngol Head Neck Surg. 1990;116:594-595)

Author Affiliations
From the Department of Otolaryngology, St Louis (Mo) Children's Hospital, The Washington University School of Medicine, St Louis (Dr Asher), and the Departments of Otolaryngology (Drs McGill, Friedman, and Healy) and Pediatrics (Dr Kaplan), The Children's Hospital, Harvard Medical School, Boston, Mass.

Footnotes
Accepted for publication January 3, 1990.

Presented at the meeting of the American Society of Pediatric Otolaryngologists, San Diego, Calif, May 18, 1989.

Reprint requests to the Group Health Cooperative, Department of Otolaryngology, 200 15th Ave E, Seattle, WA 98112 (Dr Asher).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Absent Semicircular Canals in CHARGE Syndrome: Radiologic Spectrum of Findings.
Morimoto et al.
Am. J. Neuroradiol. 2006;27:1663-1671.
ABSTRACT | FULL TEXT  

The CHARGE Association: The Role of Tracheotomy
Roger et al.
Arch Otolaryngol Head Neck Surg 1999;125:33-38.
ABSTRACT | FULL TEXT  

Ear-Nose-Throat Abnormalities in the CHARGE Association
Morgan et al.
Arch Otolaryngol Head Neck Surg 1993;119:49-54.
ABSTRACT