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Robert J. Walter, PhD; John R. Danielson, MD, PhD; Hernan M. Reyes, MD

Arch Otolaryngol Head Neck Surg. 1990;116(4):465-469.

Abstract
• Kartagener syndrome (KS) is an autosomally inherited recessive condition characterized by situs inversus, bronchiectasis, and chronic sinusitis. Ciliary dynein, the mechanochemical force generator in ciliary movement, is deficient in patients with KS. We examined blood samples from two patients and tissue biopsy specimens from five patients and found: (1) no significant defect in neutrophil or monocyte chemotaxis in response to formylpeptide chemoattractant; (2) no alterations in centriolar structure, but significantly more centriole-associated microtubules in KS neutrophils and monocytes than in control leukocytes; and (3) a marked reduction in KS fibroblast chemotaxis in response to fibronectin compared with control fibroblasts. The significance of these cellular defects in KS is described.

(Arch Otolaryngol Head Neck Surg. 1990;116:465-469)

Author Affiliations
From the Department of Surgery, Cook County Hospital and Hektoen Institute for Medical Research, Chicago, Ill.

Footnotes
Accepted for publication November 12, 1989.

Reprint requests to Department of Surgery, Division of Theoretical Surgery, Hektoen Institute for Medical Research, 625 S Wood St, Chicago, IL 60612 (Dr Walter).

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