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Kaushik A. Shastri, MD; Gerald L. Logue, MD; Mohamed Y. Zeid, MD; Arleen N. Behrens, MT(ASCP); Edwin J. Lenahan, MD; Jean G. Haar, DDS, MD

Arch Otolaryngol Head Neck Surg. 1990;116(3):350-353.

Abstract
• A 73-year-old woman developed an acquired factor VIII inhibitor in association with squamous cell carcinoma of the epiglottis. The inhibitor was an IgG antibody that reacted with factor VIII in vitro and in vivo. Intravenous -globulin therapy was successful in reducing the inhibitor so that curative surgery could be undertaken. With surgical resection of the tumor the inhibitor did not recur. The relevance of this type of coagulation disorder to the surgical management of the patient's head and neck cancer is discussed.

(Arch Otolaryngol Head Neck Surg. 1990;116:350-353)

Author Affiliations
From the Departments of Medicine (Drs Shastri, Logue, and Lenahan and Ms Behrens), Pathology (Dr Zeid), and Otolaryngology (Dr Haar), State University of New York at Buffalo, Buffalo General Hospital, and the Veterans Administration Medical Center, Buffalo, NY.

Footnotes
Accepted for publication April 21, 1989.

Reprint requests to Hematology Department, Buffalo General Hospital, 100 High St, Buffalo, NY 14203 (Dr Shastri).

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