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Leif Klinken, MD, PhD; Jens Thomsen, MD, PhD; Birgitte Bruun Rasmussen, MD, PhD; Richard J. Wiet, MD; Mirko Tos, MD, PhD

Arch Otolaryngol Head Neck Surg. 1990;116(2):202-204.

Abstract
• Acoustic neuromas are more frequent, larger, and more vascular in women, and their growth rate increases during pregnancy. Estrogen receptors were claimed to be demonstrated in these neoplasms for the first time in 1981. Since then, numerous diverging studies, using various biochemical and histochemical methods, have been published on the contents of estrogen and progesterone receptors in acoustic neuromas. We determined the content of estrogen and progesterone receptors by means of an immunohistochemical method, using monoclonal antibodies, which has proved to be reliable, reasonably sensitive, and clinically relevant in other tissues, especially in breast carcinomas. No estrogen or progesterone receptors could be found in 18 consecutive acoustic neuromas from 7 men and 11 women, ranging in age from 26 to 73 years. The results do not support preoperative hormone treatment of acoustic neuromas.

(Arch Otolaryngol Head Neck Surg. 1990;116:202-204)

Author Affiliations
From the Institute of Neuropathology (Dr Klinken), the Ear, Nose, and Throat Department, Gentofte University Hospital (Drs Thomsen and Tos), and the Institute of Pathology, Rigshospitalet (Dr Rasmussen), University of Copenhagen (Denmark); and the Department of Otolaryngology-Head Neck Surgery (Otology/Neurotology), Northwestern University, Chicago, Ill (Dr Wiet).

Footnotes
Accepted for publication August 7, 1989.

Reprint requests to Institute of Neuropathology, University of Copenhagen, 11 Frederik V's Vej, DK 2100 Copenhagen, Denmark (Dr Klinken).

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