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Correlation of Histologic Features and Prognosis

Mario A. Luna, MD; Adel El-Naggar, MD; John G. Batsakis, MD; Randall S. Weber, MD; Lisa A. Garnsey, MS; Helmuth Goepfert, MD

Arch Otolaryngol Head Neck Surg. 1990;116(11):1291-1296.

Abstract
• Flow cytometric analysis of nuclear DNA content was performed in 26 adenoid cystic carcinomas of the submandibular gland using archived, paraffin-embedded tissues. The DNA content was compared with multiple histologic parameters and clinical course. Ten carcinomas (38%) were aneuploid and 16 (62%) diploid. Aneuploid carcinomas demonstrated a higher frequency of solid cytoarchitecture, lymph node metastases, and advanced clinical stage, as compared with diploid carcinomas. Other histologic features predicting aggressive clinical behavior also correlated with abnormal DNA content and included invasion of nerves larger than 0.25 mm and intravascular extension. Our data suggest that DNA content analysis can be an effective objective parameter in the clinicopathologic assessment of adenoid cystic carcinoma.

(Arch Otolaryngol Head Neck Surg. 1990;116:1291-1296)

Author Affiliations
From the Departments of Pathology (Drs Luna, El-Naggar, and Batsakis), Head and Neck Surgery (Drs Weber and Goepfert), and Biomathematics (Ms Garnsey), University of Texas M. D. Anderson Cancer Center, Houston.

Footnotes
Accepted for publication April 24, 1990.

Read before the American Society for Head and Neck Surgery, Palm Beach, Fla, April 30-May 1, 1990.

Reprint requests to University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd, Box 35, Houston, TX 77030 (Dr Luna).

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