This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Scott J. Stern, MD; Sharon Thomsen, MD; Susan Small; Steven Jacques, PhD

Arch Otolaryngol Head Neck Surg. 1990;116(11):1259-1266.

Abstract
• To study the vascular effects of a new photosensitizing agent independent of the influence of tumor growth, a cutaneous wound model was used. Six-week-old Harlan-Sprague-Dawley "Fuzzy" rats were surgically wounded in a standard fashion. The animals were then divided into three groups: the first group received chloroaluminum - sulfonated phthalocyanine only, the second group was treated with light only, and a third group was treated with both chloroaluminum-sulfonated phthalocyanine and light. Photodynamic therapy with chloroaluminum-sulfonated phthalocyanine had a direct effect on the neovasculature of a healing wound. The vasodilatation that was seen in the wound neovasculature that occurred 12 hours after the completion of chloroaluminum-sulfonated phthalocyanine—photodynamic therapy may have indicated a therapeutic "window" at which other therapies can be employed to improve clinical efficacy.

(Arch Otolaryngol Head Neck Surg. 1990;116:1259-1266)

Author Affiliations
From the Department of Head and Neck Surgery (Dr Stern) and the Laser Biology Research Laboratory (Drs Thomsen and Jacques and Ms Small), M. D. Anderson Cancer Center, Houston, Tex.

Footnotes
Accepted for publication May 15, 1990.

Read before the 32nd Annual Meeting of the American Society of Head and Neck Surgery, West Palm Beach, Fla, May 1, 1990.

Reprint requests to Department of Head and Neck Surgery, Box 069, M. D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 (Dr Stern).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?