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A Case-Control Investigation of Risk Factors

Margaret R. Spitz, MD; John J. Fueger, MA; Helmuth Goepfert, MD; Guy R. Newell, MD

Arch Otolaryngol Head Neck Surg. 1990;116(10):1163-1166.

Abstract
• Unlike most upper aerodigestive tract cancers, salivary gland cancers are relatively infrequent, are characterized by a diversity of histologic subtypes, and have never been etiologically associated with tobacco exposure. We present the results of a case-control study of risk factors for these cancers, with risk estimates derived from self-administered comprehensive risk-factor questionnaires distributed to patients at The University of Texas M. D. Anderson Cancer Center, Houston. Cases were 64 patients with histologically confirmed salivary gland cancer. Control subjects, randomly selected from the same patient population excluding patients with cancer of the head and neck or nonmelanoma skin cancer, were frequency matched to the cases by age, sex, and ethnicity to achieve a 2:1 control subjects/cases ratio. On multivariate analysis, prior radiotherapy was a significant risk factor for both men (odds ratio [OR] = 2.1) and women (OR = 2.3). Among women, higher educational attainment (OR = 2.4), alcohol use (OR = 2.0), and hairdye use (OR = 2.5) were also significantly associated with risk. There were no significant differences between cases and control subjects with respect to tobacco exposure or specific occupational or leisure-time exposures. There is biological plausibility for associations with hairdye use and alcohol exposure.

(Arch Otolaryngol Head Neck Surg. 1990;116:1163-1166)

Author Affiliations
From the Departments of Cancer Prevention and Control (Drs Spitz and Newell, and Mr Fueger) and Head and Neck Surgery (Dr Goepfert), The University of Texas M. D. Anderson Cancer Center, Houston.

Footnotes
Accepted for publication May 15, 1990.

Reprint requests to the Department of Cancer Prevention and Control, Box 189, M. D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 (Dr Spitz).

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