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Extranodal Head and Neck LymphomaPrognosis and Patterns of Recurrence
Gary V. Burton, MD;
Susan Atwater, MD;
Michael J. Borowitz, MD, PhD;
Andrew T. Huang, MD
Arch Otolaryngol Head Neck Surg. 1990;116(1):69-73.
Abstract
• Stages I and II extranodal head and neck lymphomas treated between 1969 and 1986 were reviewed to determine prognosis and recurrence patterns. Forty-four patients had low-grade lymphoma, with 57% remaining disease free (median survival, 7.2 years). Radiotherapy provided long-term disease-free survival and palliation in the majority of patients. Relapse did not adversely affect survival. Eighty-eight patients had intermediate- or high-grade lymphoma, with 42% remaining disease free (median survival, 2.4 years). Treatment with radiotherapy alone was inadequate. Combined radiotherapy and anthracycline-containing chemotherapy appeared to be superior. Extranodal sites of first relapse were common. Central nervous system relapse was common with primary tumors located above the pterygopalatine line. Central nervous system staging and prophylactic therapy is warranted in patients with tumors above the pterygopalatine line.
(Arch Otolaryngol Head Neck Surg. 1990;116:69-73)
Author Affiliations
From the Departments of Medicine (Drs Burton and Huang) and Pathology (Drs Atwater and Borowitz), Duke University Medical Center, Durham, NC. Dr Burton is now with the Louisiana State University Medical Center, Shreveport.
Footnotes
Accepted for publication September 19, 1989.
Presented at the second International Head and Neck Oncology Research Conference, Arlington, Va, September 14, 1987.
Reprint requests to Department of Medicine, Louisiana State University Medical Center-Shreveport, 1501 Kings Hwy, Shreveport, LA 71130 (Dr Burton).
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