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Teruhiko Harada, MD; Steven K. Juhn, MD; George L. Adams, MD

Arch Otolaryngol Head Neck Surg. 1990;116(1):54-56.

Abstract
• Lysozyme concentrations in middle ear effusion and serum were determined in patients with otitis media with effusion. Lysozyme concentrations in middle ear effusion were significantly higher than in serum. Children with mucoid otitis media showed significantly higher levels of lysozyme in middle ear effusion than children with serous otitis media and adults with otitis media with effusion. Higher levels of lysozyme were observed in the group of children younger than 5 years old compared with the age group of 6- to 10year-olds. Lysozyme concentrations of middle ear effusion in adults were significantly lower than those of mucoid otitis media in children. These results indicate that lysozyme plays an important role in the disease process of otitis media.

(Arch Otolaryngol Head Neck Surg. 1990;116:54-56)

Author Affiliations
From the Department of Otolaryngology, University of Minnesota Medical School, Minneapolis. Dr Harada is now with the Mie (Japan) University School of Medicine.

Footnotes
Accepted for publication July 21, 1989.

Reprint requests to Department of Otorhinolaryngology, Mie University School of Medicine, 2-174 Edobashi, Tsu, Mie 514, Japan (Dr Harada).

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