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Shannon S. Carson, MSIV; Jiri Prazma, PhD; Stephen H. Pulver; Travis Anderson

Arch Otolaryngol Head Neck Surg. 1989;115(9):1070-1075.

Abstract
• Several authors have investigated the interaction of noise and aspirin in hearing loss, with conflicting results. We studied the combined effects of noise and high doses of aspirin on hearing in rats. Thirty-eight Sprague-Dawley rats were divided into the following five groups: (1) controls; (2) aspirin only; (3) noise only; (4) 8-day per 200 mg of aspirin per noise; and (5) 12-day per 200 mg of aspirin per noise. Auditory brain-stem–evoked responses were measured in each animal prior to, 24 hours after, and 3 weeks after aspirin and noise exposure. The animals were killed and hair cells were counted in 200-µm segments and expressed graphically. Results showed significant differences in permanent threshold shift and hair cell loss between all noise-exposed animals and non–noise-exposed animals. There was also a significantly greater amount of hair cell loss in group 5 when compared with groups 3 or 4. The 12-day per 200 mg of aspirin per noise regimen (group 5) also proved to be fatal for 6 of 15 of these animals, and caused significant weight loss in the survivors. No weight loss or deaths were noted in any other group.

(Arch Otolaryngol Head Neck Surg. 1989;113:1070-1075)

Author Affiliations
From the Division of Otolaryngology–Head and Neck Surgery, University of North Carolina School of Medicine, Chapel Hill.

Footnotes
Accepted for publication April 13, 1989.

Presented in part at the 10th midwinter meeting of the Association for Research in Otolaryngology, Clearwater Beach, Fla, February 1987.

Reprint requests to Division of Otolaryngology–Head and Neck Surgery, CB 7070,610 Burnett-Womack Bldg, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7070 (Dr Prazma).

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