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Relationship of Clinical Response and Serum Concentrations of Total and Specific IgE Antibody Levels

Benedetto Testa, MD; Francesco Mazzei, MD; Massimo Mesolella; Arturo Maione, MD; Domenico Testa; Carlo Mesolella, MD

Arch Otolaryngol Head Neck Surg. 1989;115(8):950-953.

Abstract
• During a double-blind clinical trial of a histamine (H₂) antagonist (ranitidine) in monitoring allergic rhinitis, the clinical response, total serum IgE levels, and Parietaria IgE antibody levels were measured. Ranitidine induces an improvement in scores of subjective and objective symptoms, a decrease in total serum IgE levels, and no significant variations in Parietaria IgE antibody levels. Since H₂ antagonists seem to induce these improvements by acting on suppressor T cells bearing H₂ receptor, as shown in our previous studies, it is hypothesized that the lymphocytic subset that regulates the total IgE synthesis is not the same as that governing specific IgE synthesis.

(Arch Otolaryngol Head Neck Surg. 1989;115:950-953)

Author Affiliations
From the Institute of Otolaryngology, First School of Medicine, University of Naples (Italy).

Footnotes
Accepted for publication January 31, 1989.

Reprint requests to Clinica Otorinolaringoiatrica, I Facoltà di Medicina dell'Università di Napoli, Ospedale Gesù e Maria, Via Cotugno 3, 80135 Naples, Italy (Dr Testa).

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