This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

A Randomized, Double-blind, Placebo-Controlled Study

Jens Thomsen, MD, PhD; Jørgen Sederberg-Olsen, MD; Viggo Balle, MD; René Vejlsgaard, MD, PhD; Sven-Eric Stangerup, MD; Göran Bondesson, PhD

Arch Otolaryngol Head Neck Surg. 1989;115(4):447-451.

Abstract
• A double-blind, randomized, place-bo-controlled clinical trial was conducted to evaluate one month of amoxicillinclavulanate potassium treatment of children with secretory otitis media. In total, 264 children, aged 1 to 10 years, were randomly assigned to either antibiotic or placebo treatment; 43 patients were excluded during treatment, equally distributed in both groups, leaving 221 patients completing the trial. The inclusion criterion was a type C₂ and type B tympanometry result of at least three months' duration. Tympanometry was performed every month for 12 additional months. At the end of the treatment period, the disease was reversed in 61% in the antibiotic-treated group compared with 30% in the placebo-treated group P<.0001), and the improvement was

Author Affiliations
From the Ear-Nose-Throat Department, Gentofte University Hospital, Hellerup (Drs Thomsen, Balle, Stangerup, and Bondesson); the Department of Clinical Microbiology, Herlev University Hospital (Dr Vejlsgaard), and the Ear-Nose-Throat Clinic (Dr Sederberg-Olsen), Helsingør, Denmark.

Footnotes
Accepted for publication Oct 7, 1988.

Reprint requests to the Ear-Nose-Throat Department, Gentofte University Hospital, DK-2900 Hellerup, Denmark (Dr Thomsen).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Antibiotic Treatment of Children With Secretory Otitis Media: Amoxicillin-Clavulanate Is Superior to Penicillin V in a Double-blind Randomized Study
Thomsen et al.
Arch Otolaryngol Head Neck Surg 1997;123:695-699.
ABSTRACT  

Use of Antibiotics in Preventing Recurrent Acute Otitis Media and in Treating Otitis Media With Effusion: A Meta-analytic Attempt to Resolve the Brouhaha
Williams et al.
JAMA 1993;270:1344-1351.
ABSTRACT  

Autoinflation as a Treatment of Secretory Otitis Media: A Randomized Controlled Study
Stangerup et al.
Arch Otolaryngol Head Neck Surg 1992;118:149-152.
ABSTRACT  

Antimicrobial Therapy for Otitis Media With Effusion ('Secretory' Otitis Media)
Cantekin et al.
JAMA 1991;266:3309-3317.
ABSTRACT  

Antibiotics for Secretory Otitis Media
CANTEKIN
Arch Otolaryngol Head Neck Surg 1990;116:626-628.
ABSTRACT  

Antibiotic Treatment of Children With Secretory Otitis Media
SHAMBAUGH
Arch Otolaryngol Head Neck Surg 1990;116:108-108.
ABSTRACT