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Effects of Thymosin 1 In Vitro

Gregory T. Wolf, MD; Jerry Hudson, PhD; Karen A. Peterson; Judy A. Poore; Kenneth D. McClatchey, MD

Arch Otolaryngol Head Neck Surg. 1989;115(11):1345-1349.

Abstract
• Altered cellular immunity in patients with advanced head and neck cancer includes impairments in lymphokine production, blastogenesis, in vitro cytotoxicity, and T-cell levels. Recent evidence for the potential importance of in vivo cytotoxicity mediated by the lymphokine interleukin 2 (IL-2) in patients with cancer prompted a study of the kinetics of IL-2 receptor expression on lymphocytes from patients with untreated advanced head and neck cancer and normal subjects and an evaluation of the in vitro effects of the T-cell immune-reconstituting peptide, thymosin ₁. Concanavalin A—stimulated IL-2 receptor expression was maximal after 72 hours and was higher in normal subjects than in patients. This was due to lower levels of helper/inducer (CD4) cells

Author Affiliations
From the Departments of Otolaryngology-Head and Neck Surgery (Dr Wolf and Mss Peterson and Poore) and Pathology (Drs Hudson and McClatchey), University of Michigan and Veterans Administration Medical Center, Ann Arbor.

Footnotes
Accepted for publication December 16, 1988.

Read before the Second International Conference on Head and Neck Cancer, Boston, Mass, August 2, 1988.

Reprint requests to Department of Otolaryngology–Head and Neck Surgery, 1904 Taubman Health Center, 1500 E Medical Center Dr, Ann Arbor, MI 48109-0312 (Dr Wolf).

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